A deepfake of Facebook CEO Mark Zuckerberg is making the rounds a month after his company refused to remove similar videos.

Last month, Facebook refused to remove a deepfake video of House Speaker Nancy Pelosi. Rather than making Pelosi appear to say things she never did, the video aimed to portray her as being intoxicated.

Deepfakes have the potential to spread misinformation and damage the reputation of individuals. Particularly in the world of politics and...